Semi-Automated Optical Heartbeat Analysis Software
Click play to watch a video under microscope of the beating heart of a Drosophila melanogaster
SOHA was originally written as a MatLab-based application and its implementation was published in Ocorr et al., 2007. The original program resulted from a collaboration between researchers at the Sanford-Burnham Medical Research Institute and the University of California – San Diego.
A more detailed demonstration of its application to fruit flies and to other model systems with small hearts was presented in Fink et al, 2009 and Ocorr et al, 2009.
Quantifies Movement from Videos
- Sensitive
- Non-invasive
- Good signal/noise ratio
- Resolution is limited only by the movie frame rate
Successfully used to quantify movement from:
- Drosophila melanogaster hearts
- Zebrafish larval hearts
- Embryonic mouse hearts (E9)